There is no clear contraindication to the use of Adapalene Gel with Mupirocin Ointment, but they are generally not used at the same time, and it is recommended that they be used in accordance with medical advice. Adapalene Gel has anti-inflammatory properties and is used for the topical treatment of mild-to-moderate common acne presenting as papules, pimples, and pustules. It can be used to treat acne on the chest and back, and face. Adverse reactions to this product can be seen as skin irritation, dry skin, burning sensation, and erythema. It is contraindicated in people who are allergic to this product. Mupirocin is a topical antibiotic indicated for superficial wound co-infections, eczema co-infections, skin infections such as impetigo, folliculitis, boils and other primary skin infections. Adverse effects of this product can be seen as local stinging sensation, burning sensation, itching. It is contraindicated for those who are allergic to this product. Adapalene gel and mupirocin instructions do not indicate that the two will occur drug interactions, but mupirocin is mainly used for skin breakouts, adapalene is irritating, if used at the same time can aggravate the symptoms of irritation, so it is not recommended to use at the same time. Specifically, please follow the doctor’s instructions for medication, do not self-medication.