There is no clear clinical standard on how big a wound needs to be vaccinated against tetanus, as long as the patient’s wound is deep and may create a living environment for the Clostridium tetani bacteria, it needs to be vaccinated against tetanus. Tetanus is an acute infectious disease caused by Clostridium tetani infection, and once the disease develops, the mortality rate is extremely high. Clostridium tetani is an anaerobic bacterium, and if the patient has a deep wound, it can create favorable conditions for its growth and reproduction. Especially small and deep wounds are most likely to form an anaerobic environment. Injection of tetanus antitoxin within 24h after injury can effectively prevent C. tetani infection. Currently, there is no clinical standard that specifies how big a wound needs to be vaccinated against tetanus. It is recommended that patients go to the hospital for debridement first, and then follow the doctor’s advice to decide whether tetanus vaccination is needed.