Talking nonsense 2 days after meningioma surgery is mostly caused by drug anesthesia, secondary brain tissue edema caused by postoperative, severe hyponatremia, tumor’s influence on hormone and blood flow, etc. It is recommended to treat the specific causes. 1. Drug anesthesia: general anesthesia is used for the patients during the operation. After the operation, because of the anesthesia, the patients will speak nonsense, have pain, be nervous and so on, which will be gradually recovered in 3~5 days, and the family members need not worry about it. 2. Secondary cerebral edema: If the patient has secondary cerebral edema after surgery, it will lead to headache, nausea, dry heaving, and may be accompanied by babbling, irritability, emotional abnormalities and other phenomena, which should be given to the patient in time to apply the dehydration to reduce intracranial pressure medication, such as mannitol and so on, in accordance with the medical advice. 3. Severe hyponatremia: patients may have severe hyponatremia after meningioma surgery, which may be accompanied by obvious mental abnormality, gibberish and other symptoms, and need to be given sodium supplementation treatment. 4. Impact of tumor on hormone and blood flow: the size and location of meningioma will also affect the postoperative mental state. For example, meningioma near the saddle area may have similar symptoms due to hormone regulation disorder, and huge meningioma may have mental symptoms due to the change of blood perfusion after surgery. After meningioma surgery, we should do a good job of patient care, and if there is any abnormality, we should consult a doctor in time for targeted treatment.