In daily life skull defect repair is a common procedure in brain surgery. Cranial injury not only affects the quality of life of patients, but also leads to death, so cranial injury must be operated in time. So how to take care of the skull defect repair after surgery? 1, need to pay attention to the change of sanity. The vast majority of patients after skull repair surgery, a day later will be the state of consciousness, if after surgery, the patient’s consciousness still long time without obvious signs of awakening, and vital signs produce disorder performance, and the pupils appear dilated, must promptly inform the doctor, may be intracranial hemorrhage, hydrocephalus performance, early corresponding treatment, otherwise it may lead to the patient The death of the patient. 2. The patient’s vital signs need to be closely observed, mainly by paying close attention to the patient’s body temperature. Once the temperature rises, the doctor should be informed in time to conduct the corresponding examination to exclude intracranial infection, lung infection, urinary system infection and other infections. 3.The patient needs to be turned and patted on the back every day, regular sputum aspiration, shock excretion, active movement of the lower limbs, and if they can get out of bed, assist them to get out of bed for rehabilitation functional exercise as early as possible, which can effectively reduce the chance of various complications such as lung infection and lower limb venous thrombosis. 4, actively improve the patient’s nutritional status, give appropriate daily diet, need to pay attention to the patient’s urinary and fecal status, to minimize the occurrence of constipation diarrhea and other adverse conditions. 5, pay attention to the changes of the patient’s wound, give regular dressing changes, if the wound appears bleeding and oozing, bleeding and pus and other adverse conditions, promptly inform the doctor for re-cleaning and suturing treatment.