The side effects of tenofovir disoproxil fumarate are mainly related to the skeletal and muscular system, digestive system, and renal impairment, etc. Tenofovir disoproxil fumarate is an antiviral drug, and the use of tenofovir disoproxil fumarate may reduce bone density, such as causing osteoporosis, or even lead to bone fracture, so patients who have been bedridden for a long period of time, have insufficient intake of calcium, are addicted to cigarettes and alcohol, or who are using hormones, should have their bone density checked regularly, and take calcium supplements or vitamin D under the guidance of their doctors if necessary. Tenofovir disoproxil fumarate can also cause renal impairment, so kidney function should be monitored during use. If you experience persistent bone pain or pain in the limbs, muscle pain, or weakness, have your kidney function checked by a healthcare provider immediately. It can also cause gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, and vomiting. Discontinuation of tenofovir disoproxil fumarate in patients with hepatitis B may cause an exacerbation of hepatitis, so liver function should be monitored closely for several months after discontinuing the drug. If sudden symptoms such as headache, dizziness, insomnia, depression, rash, itching, fever, etc. occur while taking the medication, stop taking the medication immediately and go to a local regular medical institution.