Hyaluronic acid injection filling is effective for penis enlargement, but it is not permanent, with the passage of time, the filled hyaluronic acid will be absorbed by the organism, but due to the large amount of hyaluronic acid used in penis filling, it usually takes 2~3 years to be completely absorbed, and then there is no more thickening effect. Hyaluronic acid injection filling penis enlargement is through the injection of hyaluronic acid into the tissue space between the cavernous body of the penis, through the filling to achieve the purpose of penis enlargement, although less traumatic, but there are still some risks. The most common is the displacement of hyaluronic acid, resulting in irregular penile shape, affecting aesthetics, and may also produce symptoms of vascular and nerve compression. Secondly, the injection operation requires a high level of physician, it may happen that hyaluronic acid is mistakenly injected into the cavernous body of the penis or blood vessels, in which case edema occurs in the light case, and in the heavy case, vascular embolism may occur, affecting the erectile function of the penis. Therefore, for hyaluronic acid genital plastic surgery, must strictly grasp the indications, and to the regular hospital by a professional doctor to avoid accidents.