Nerve block refers to blocking the vicious cycle of pain, reducing the sensitivity of peripheral and central nervous system, eliminating inflammation, reducing edema, relaxing muscles, and improving local blood circulation, accelerating the metabolism of pain-causing substances, and promoting the repair of damaged nerves, thus relieving or alleviating pain. It is a drug injection according to the route and innervation of nerves. The drugs used are more reasonable, more extensive and safer. The scope of application is broader, not only for clinical analgesia and treatment, but also for diagnosis, prognosis and disease prevention. And the technique is more difficult, more complicated and more precise, and it is applicable to various painful and non-painful diseases (such as spasm, paralysis, etc.). In contrast, closure therapy originated in the former Soviet Union, also known as procaine closure therapy, is the injection of procaine into the body’s local pain points to play a temporary pain relief effect, which can be simply understood as which pain hit which. As the most basic means of pain treatment, nerve block therapy can play a greater role in relieving the pain for the majority of pain patients.