It is less likely for patients with advanced rectal cancer to live 20 years, but it is not completely impossible, especially for patients with locally advanced stage, they may survive 20 years if the tumor is removed through surgery, supplemented by radiotherapy, chemotherapy, targeted therapy, etc., plus the patients’ own high quality, good mentality and strengthened review. As the early symptoms of rectal cancer are not obvious, most patients have already developed to the middle and late stage when they are diagnosed, and the 5-year survival rate of late stage patients is about 5%-8%. The specific survival time of late stage rectal cancer is related to various factors such as disease condition, location, metastasis, patient’s physical condition, etc. Patients with locally advanced stage or single metastasis have the possibility of long-term survival after surgical treatment as well as radiotherapy and chemotherapy. Maintaining a good state of mind during anti-cancer treatment can also significantly help prolong the survival time of patients with advanced rectal cancer. At the same time, it is important to eat less greasy, fried, smoked and pickled foods in life, and eat fruits and vegetables rich in vitamins, such as apples, spinach, oranges, etc. in appropriate amount. Regular review is very important, once rectal cancer recurrence or metastasis is found, timely treatment is needed to avoid the progress of the disease.