When patients with acute painful attacks of cholecystitis caused by gallbladder stones go to the hospital, it is common practice for doctors to give them fluids, anti-inflammatory and antispasmodic treatments. We call it non-surgical or conservative treatment with this infusion method. Conservative treatment is effective in the majority (80%) of patients with pain caused by gallbladder stones, while it is ineffective in a small percentage (20%) of patients. In addition, not every conservative treatment is effective in relieving pain, and the last conservative treatment that was effective may not be effective this time. Sometimes, when a patient does not do well with infusion therapy, he or she may say that the doctor prescribed the wrong medication this time or that he or she does not know how to see the patient. I once met a patient who came to see a doctor after an attack of biliary colic and said to the doctor with his medical record: “You should write the prescription according to the medicine written in the last medical record, I have used this medicine for several pain attacks, and I got better as soon as the “water” was hung. But this time, the same prescription did not work. Why is that? We know that gallbladder stones cause pain because they become lodged in the neck of the gallbladder. The inflamed gallbladder wall will have inflammatory exudate, and the exudate will cause the pressure in the gallbladder cavity to increase, and the cavity of the gallbladder wall in the neck will be enlarged, and the embedded stones will be loosened and can fall into the gallbladder cavity, so that the bile can flow out through the cystic duct and the pain will disappear. In a small number of patients, if the stone is still embedded, the pain persists. Conservative treatment, such as infusion, can provide anti-inflammatory and pain relief, but cannot eliminate the pain. Patients with persistent painful stones in the neck of the gallbladder often need emergency surgery, otherwise gangrene (death) of the gallbladder wall, perforation and peritonitis can occur, more easily in elderly patients. This is especially important in the elderly because of their insensitivity to pain and other reactions.