Causes of large red bumps on the skin that are very itchy include papular urticaria, scabies, folliculitis, eczema, etc. Treatment includes medication and so on. 1. Pemphigus urticaria: If pemphigus urticaria is considered, anti-allergic treatment such as dicloxacortin and ebastine can be given at this time. 2. Scabies: If it is scabies, you can give 5% triclopyr cream and other drugs to kill scabies treatment. 3. Folliculitis: When folliculitis is considered, drugs such as amoxicillin and tinidazole can be used for antibacterial treatment. 4. Eczema: for patients with eczema, drugs such as sodium thiosulfate need to be given at this time for anti-allergy treatment. Finally, the appearance of large red bumps on the skin is very itchy phenomenon, please consult a doctor in time, the above drugs need to follow the doctor’s advice, do not self-medication.