If a patient experiences recurrent low back pain and discomfort, or even fever, night sweats, or hypothermia, he or she should go to the hospital for a specialist examination as soon as possible. In the early stages of spondylitis, an orthopedic examination is required. The doctor will take a detailed medical history, which will give a general idea of the basic condition and nature of the disease. Laboratory tests, such as routine blood tests, C-reactive protein, sedimentation, serum tissue antibodies, HLA-B27, and rheumatoid factor, can also provide a glimpse of the beginning of the disease. In addition, imaging tests such as X-rays, CT, and MRI can also help determine the site of spondylitis. There are also special tests, including electromyography and nerve conduction evoked potentials, which can provide a comprehensive assessment of the occurrence of spondylitis and also allow for early intervention. The differential diagnosis of the different manifestations of spondylitis can be made by laboratory tests and imaging. Once the condition occurs, most patients with spondylitis can usually be treated very well with early intervention and treatment, so it is important to go to the hospital as early as possible for examination and timely treatment.