Azithromycin and roxithromycin are a class of antibiotics, both belong to macrolide antibiotics, clinically to destroy germ proteins to achieve growth inhibition and kill bacteria. Both are not recommended for repeated application, more than one sensitive bacteria to control the patient’s condition, especially for the infection caused by mycoplasma and chlamydia is ideal. For different sites, like pneumonia, skin and soft tissue infections, urinary system infections can be applied selectively. Roxithromycin and azithromycin can be used in combination with phlegmolytic and asthma medications for the treatment of Mycoplasma pneumoniae infection. Patients should drink more water and eat more fresh fruits and vegetables, its also helpful to enhance the effectiveness of the medication.