Drinking alcohol after taking cefixime can cause a disulfiram-like reaction, which is an allergic-like lethal reaction between cephalosporins and beta-lactams and ethanol in alcohol, and requires immediate observation of the patient’s condition. If the patient develops itchy skin or a red rash or maculopapular rash accompanied by difficulty in breathing, the patient needs to seek immediate medical attention and the patient should drink more warm water and try to induce vomiting so that the patient tries to vomit the alcohol consumed through the gastrointestinal tract to avoid the next step of alcohol absorption and digestion in the gastrointestinal tract. When you arrive at the hospital, you should talk to the doctor about your medical history and be given some anti-allergy medication quickly. In addition, if the patient has a severe disulfiram-like reaction, he or she should be given epinephrine immediately for anti-shock treatment.