Cervical cord demyelination changes are mainly seen in optic neuromyelitis optica, multiple sclerosis, myelitis and other central nervous system demyelinating diseases, and the treatment includes acute-phase treatment, remission-phase treatment and symptomatic treatment. 1. Acute stage: In the acute stage, glucocorticoid shock therapy is used, such as intravenous methylprednisolone infusion and oral prednisone, and the principle is high dose and short course of treatment. 2. Remission period: according to the disease can be selected immune system, such as azathioprine, cyclophosphamide, merti-macrolide, etc.; disease modification therapy, such as teriflunomide, cinimod, dimethyl fumarate, etc.; B-cell immunity, such as rituximab and other treatments. 3. Symptomatic treatment: Carbamazepine or pregabalin can be applied for spasticity and pain symptoms; those with limb dysfunction need to be treated with rehabilitation exercise and acupuncture and massage in the later stage to improve the prognosis and quality of life. When the cervical cord demyelination changes are found, the cause should be clarified under the guidance of the doctor, and the treatment should be standardized according to the disease, do not blindly self-medication.