Dysplasia of the ear is one of the symptoms of pediatric Diegeorg’s syndrome. Diegeorg’s syndrome (DGS) is associated with chromosome 22q11 defect and should be considered as the sum of the most severe group of clinical disorders, abbreviated by the first letter of each word as ldquo;CATCHrdquo; 22 syndrome, meaning Cardiac deficiency (Cardiac), Facial abnormality (Abnormal), Thymic hypoplasia (Thymic), Epiglottis (Cleft) and Hypocalcemia due to 22q11 deletion. Thymic), epiglottis malformation (Cleft) and decreased blood calcium (Hypocalcemia). 1. Maternal health The occurrence of some immunodeficiency diseases is known to be closely related to embryonic dysplasia. If a pregnant woman is exposed to radiation, treated with certain chemical drugs or has a viral infection (especially rubella virus infection), the immune system of the fetus can be damaged, especially in early pregnancy, and multiple systems, including the immune system, can be affected. Therefore, it is very important to strengthen maternal health care, especially in early pregnancy. Pregnant women should avoid receiving radiation, use some chemical drugs carefully, and take rubella vaccination to prevent viral infection as much as possible. Pregnant women should also strengthen nutrition and timely treatment of some chronic diseases. 2, genetic counseling and family investigation Although most diseases cannot be determined the mode of inheritance, genetic counseling is valuable for those diseases for which the mode of inheritance is determined. If an adult has an inherited immunodeficiency disease will provide the developmental risk of their children; if a child has an autosomal recessive or sex-linked immunodeficiency disease, parents should be told how likely their next child is to have the disease. Immediate family members of patients with antibody or complement deficiencies should be tested for antibody and complement levels to determine the familial pattern of disease. For certain diseases for which genetic localization is available, such as chronic sarcoidosis, the patient’s parents, siblings and their children should be tested for localized genes, and if a patient is found, the same should be done in his or her family members, and the patient’s children should be carefully monitored for the occurrence of the disease from birth. 3, prenatal diagnosis Certain immunodeficiency diseases can be diagnosed prenatally, such as cultured amniotic fluid cell enzymatic tests can diagnose adenosine deaminase deficiency, nucleoside phosphorylase deficiency and certain combined immunodeficiency diseases; fetal blood cell immunological tests can diagnose CGD, X-linked gammaglobulinemia, severe combined immunodeficiency diseases, so as to interrupt pregnancy and prevent the birth of affected children. The chance of transmitting the disease to the offspring is 50% in patients with Diegeorg’s syndrome, and prenatal diagnosis can be made by finding 22q11 deletion in amniotic fluid cells or chorionic villus cells by chromosome analysis. Parents with congenital heart disease or diagnosed with 22q11 deletion are the focus of prenatal screening, and prenatal ultrasonography can detect cardiac malformations. Based on the above, early and accurate diagnosis can be made and early specific treatment and genetic counseling (prenatal diagnosis or even intrauterine treatment) is very important.