Dysplasia of the ear is one of the symptoms of pediatric Diegeorg’s syndrome. Diegeorg’s syndrome (DGS) is associated with chromosome 22q11 defect and should be considered as the sum of the most severe group of clinical disorders, abbreviated by the first letter of each word as ldquo;CATCHrdquo; 22 syndrome, meaning Cardiac deficiency (Cardiac), Facial abnormality (Abnormal), Thymic hypoplasia (Thymic), Epiglottis (Cleft) and Hypocalcemia due to 22q11 deletion. Thymic), epiglottis malformation (Cleft) and decreased blood calcium (Hypocalcemia). Electrolyte and hormone tests revealed low serum calcium and high phosphorus, and reduced or deficient parathyroid hormone. 2. Immune function tests Among 18 cases of cardiac surgery, only 3 cases could see thymus in the mediastinum. (1) Incomplete DGS: There was residual thymic tissue with normal T lymphocyte proliferative response and significantly reduced T11 cell function. The lymphocyte count at birth was 500-1500/mm3, and basically reached the normal range at 1 year of age. the number of B cells was normal or even increased, and there could be high IgGemia, high antibody response and autoantibodies. The affinity and persistence of the antibody response to vaccines have also been reported to be inferior to those of normal children of the same age. (2) Complete DGS: The presence or absence of residual thymic tissue is not a criterion for determining complete DGS, but a defective proliferative response of T cells can be recognized as complete DGS. an increase in the number of T cells with age does not improve their proliferative response. the number of NK cells also decreases, and their number and function are impaired to the same extent as that of T cells. the number of B cells increases, and immunoglobulins may appear The number of B cells is increased or decreased, IgA deficiency and low anti-diphtheria-tetanus toxoid-specific antibodies. 3. Prenatal diagnosis and identification of disease carriers Patients with DGS have a 50% chance of transmitting the disease to their offspring, and prenatal diagnosis can be made by finding a 22q11 deletion in amniotic fluid cells or chorionic villus cells by chromosome analysis. Those whose parents have congenital heart disease or have been diagnosed with 22q11 deletion are the focus of prenatal screening. Prenatal ultrasonography can detect cardiac malformations. Although the 1st child with DGS is rarely seen to develop the 2nd child as well, prenatal examination should still be performed. 4.Imaging: Chest radiography may suggest no thymic shadow, but this does not exactly mean abnormal T-cell capacity. x-ray reveals cardiac and macrovascular abnormalities, such as right posterior arterial arch, dilated pulmonary artery and enlarged heart. Resonance reveals small cerebellar earthworms and posterior cranial recesses as well as small cyst formation near the anterior horn in some cases. Echocardiography can clarify the type of cardiac malformation, and prenatal ultrasonography can detect cardiac malformations. Brain CT, electroencephalogram and cardiovascular imaging should be done.