Cephalosporin 12 hours after drinking, if only a small amount of alcohol and no uncomfortable symptoms, should be closely observed, drink a lot of water, appropriate vomiting and other ways to deal with. If uncomfortable symptoms appear, you should immediately go to the hospital for treatment. Within 7 days after drinking alcohol, taking cephalosporin more or less will cause disulfiram-like reaction, such as drinking alcohol 12 hours after taking cephalosporin will cause mild to moderate disulfiram-like reaction. In mild cases, it will cause skin allergy, such as rash, red rash, maculopapular rash, itchy skin, fused into patches, and even skin-like changes such as vesicles and oozing. In severe cases, chest tightness, shortness of breath, palpitations, discomfort in the precordial area, and arrhythmia may occur. In more serious cases, there will be dizziness, headache, projectile vomiting, transient consciousness disorder or even unconsciousness. In the most severe cases, the clinical symptoms of anaphylaxis may occur. If only a small amount of alcohol and no obvious discomfort, need to immediately stop taking cephalosporins, stop drinking alcohol. You should drink enough water to promote excretion, appropriate treatment of vomiting, and keep observation. If the amount of alcohol consumption is relatively large, there may be a certain amount of alcohol 12 hours after drinking, after taking cephalosporin appeared the above symptoms of poisoning, should be carried to the hospital in a timely manner to take the drugs to the hospital for treatment, so as not to affect or delay the condition. In ordinary life, during the treatment of taking cephalosporins, attention should be paid to avoid drinking alcohol within 1 week.