The part of the body that produces cold sensation is the somatosensory center of the cerebral cortex. Cold sensation is the sensation produced by low temperature stimulation of the skin. The process of cold sensation is: cold stimulates the cold receptors in the skin Klaus’s bulb, through the relevant afferent nerves to the cerebral cortex of the somatosensory center and produce cold sensation. The human thermoregulatory center is the hypothalamus. Skin cold receptors receive cold stimuli through the relevant nerves into the hypothalamus, the hypothalamus through the efferent nerves, regulating the secretion of adrenaline, so that the erector spinae muscle contraction, skeletal muscle trembling, capillary constriction, sweat glands to reduce the secretion of the body temperature rise. Therefore, the production site of cold feeling is the cerebral cortex, the regulation of body temperature center is the hypothalamus, pay attention not to confuse the two, the body of the body temperature feeling abnormal, timely medical treatment, to avoid the development of the disease.