Prolonged cough with sputum may be caused by respiratory diseases, circulatory diseases, digestive diseases, etc., and need to be treated according to the specific causes. 1. Respiratory diseases: cough, cough sputum is the most common symptom of respiratory diseases, respiratory diseases such as bronchitis, especially chronic bronchitis can cause prolonged cough, can be used to aminoglutethimide or Pentoxyverine cough phlegm. 2. Circulatory system diseases: such as left heart failure will also show cough, cough pink foamy sputum, fatigue, chest tightness, shortness of breath and other symptoms, treatment to deal with the primary disease, can be given to hydrochlorothiazide, furosemide diuretic, metoprolol to reduce myocardial oxygen consumption, digoxin to improve the symptoms of heart failure. 3. Digestive system diseases: cough caused by gastroesophageal reflux disease, need to take omeprazole for acid suppression therapy. Prolonged cough with phlegm may also be other causes, it is recommended to seek professional medical help, receive standardized treatment, so as not to delay the condition.