Systemic sclerosis is a systemic autoimmune disease that involves small arteries, microvessels, and extensive connective tissue. The main features are fibrosis and vascular occlusion of the skin, gastrointestinal tract, lungs, heart and kidneys. The clinical features are skin sclerosis and eventually visceral damage. The etiology of systemic sclerosis is unclear and may be related to genetics, viral infections, and environmental factors such as exposure to chemicals such as silica and long-term use of certain drugs such as isoniazid and bleomycin. Cellular and humoral immune abnormalities increase the synthesis and secretion of collagen by fibroblasts, leading to skin and visceral fibrosis. Patient prognosis is determined by the extent and degree of skin involvement, as well as damage to internal organs. If scleroderma, renal crisis and pulmonary hypertension and interstitial pulmonary fibrosis are already present, the patient’s prognosis is relatively poor.