Patients with nail fungus with localized anaerobic bacterial growth can be disinfected with hydrogen peroxide to kill localized anaerobic bacteria. Most patients with nail fungus have acute or chronic inflammation due to localized nail ingrowth into the flesh. For nail infections with Staphylococcus aureus, disinfection with hydrogen peroxide does not kill the bacteria. Therefore, when there is local inflammation, it is possible to strengthen the anti-infective treatment by applying 0.5% iodophor gauze topically and taking anti-inflammatory drugs such as amoxicillin orally, which can achieve better results in mild cases of nail infection. If the patient’s nail infection is accompanied by local abscess formation, the effect of drug treatment alone is often poor, and surgical incision of the abscess and nail removal can be considered to cure the nail infection.