Small blisters in the middle of the toes with itching symptoms, considering the possibility of tinea pedis, it is recommended to further clarify the diagnosis based on the results of fungal microscopy. If the fungal microscopy test results show (+) is suggestive of tinea pedis, you can use topical miconazole cream, clotrimazole cream and other topical topical, to play the role of antifungal. If the fungal microscopy shows (-), then consider the possibility of acute eczema, you can use topical topical glucocorticoid ointment, such as dinexed ointment or mometasone furoate cream. For patients with intense itching, oral antihistamines can be considered to reduce the symptoms of itching. In addition, because of localized itching patients will inevitably scratch with their hands, need to be vigilant to avoid scratching and hot water scalding, so as to avoid secondary local infection.