Pain in the middle of the foot, the common clinical causes are mainly the following: First, interstitial purulent infection of the foot, mostly due to the foot skin rupture, the patient did not disinfect the treatment as soon as possible, the skin surface bacteria along the rupture into the soles of the feet and caused by acute inflammatory reaction. Patients may be accompanied by obvious swelling of the foot, elevated skin temperature and pain. At this time, it is necessary to perform a surgical incision of the foot interspace as soon as possible to drain out the fluid and pus in the interspace. Strengthen the intravenous anti-infection treatment, the symptoms of pain in the middle of the foot can be relieved faster. Second, gout, the body of purine metabolism abnormal patients if eat more seafood, animal offal and other foods, will cause the body of uric acid indicators significantly higher, a large number of uric acid accumulation in the joints of the feet and other places, can cause the middle of the foot obvious pain symptoms. At this time, patients can take oral colchicine, sodium bicarbonate, feet external application of Xuanming powder to improve the symptoms of pain in the middle of the foot.