Cold in the middle of the night diarrhea may be a viral infection, toxin attack on the human body due to cold may also be diarrhea dehydration, severe pain, hypoglycemia and other causes, according to the different reasons for different ways to deal with. 1. Viral infection: It may be a viral infection of the gastrointestinal tract, triggering gastrointestinal tract dysfunction, at the same time its toxin invasion of the human body, there may be a diarrhea in the middle of the night on the body of the situation of the cold, you can use montelukast to protect the intestinal mucosa, to alleviate diarrhea. Drink more hot water, add clothing and keep warm. If there is intestinal infection, should take levofloxacin and other anti-infective drugs. 2. Dehydration: If diarrhea is severe, lose a lot of water and electrolytes, dehydration, may also appear on the body cold, this situation should drink rehydration salts or infusion, correct electrolyte disorders. 3. severe pain: if diarrhea when the gastrointestinal tract smooth muscle spasms, severe pain, autonomic disorders, may also occur the phenomenon, you can use scopolamine, belladonna tablets, etc. to relieve gastrointestinal smooth muscle spasms, reduce abdominal pain. 4. Hypoglycemia: eating less during diarrhea, insufficient carbohydrate supplementation, hypoglycemia may also occur on the body chills, you can drink glucose solution, eat sugar and so on. It is recommended to consult a doctor in a timely manner, under the guidance of the doctor to identify the causes and to carry out reasonable treatment, so as not to delay the condition.