Mild nephritis does not affect the fertility of patients, while severe nephritis requires the application of hormone or immunosuppressant treatment may have a certain impact on fertility, in addition to nephritis if it develops into renal insufficiency will also have a certain impact on fertility. For male patients, nephritis has no significant effect on sperm development and does not affect the patient’s sexual function. Mild nephritis is usually treated with angiotensin II receptor antagonists, such as Irbesartan, etc. These drugs do not have a significant effect on male sperm, but it is usually recommended to discontinue the drug for a period of time before considering childbearing. For severe nephritis that requires hormone or immunosuppressant treatment, such as prednisone or cyclophosphamide, these drugs may affect sperm development, or the progression of nephritis to renal failure, which may have some impact on fertility. For women who are not pregnant, mild nephritis has little effect on fertility. In severe nephritis, especially if it progresses to renal failure, or when medications such as immunosuppressants are applied, it may affect the patient’s ovulation and may have an impact on fertility. For women who are already pregnant, mild nephritis usually does not cause miscarriage or fetal malformation. However, during fetal development, it may increase the burden on the kidneys, or severe nephritis requires the use of immunosuppressants, such as cyclophosphamide tablets, cyclosporine soft capsules, tacrolimus capsules and so on, and these drugs may affect fetal development. All of the above medications should be used in accordance with the doctor’s instructions, avoid self-medication. If patients with nephritis consider fertility problems, it is recommended to go to regular hospitals in time, under the guidance of the doctor’s treatment.