If the ankle bone is swollen, we should first rule out the presence of local trauma to the ankle bone or the presence of sedentary or sedentary. In addition to this, we should consider some medical diseases, which may also appear swollen ankle bones, as follows: 1. Kidney diseases: when proteinuria occurs, especially massive proteinuria and hypoproteinemia, swelling of both lower limbs or swollen eyelids may easily appear, and even thoracic fluid and ascites may appear; 2. Heart diseases: when there are underlying cardiovascular diseases, such as coronary heart disease and post-infarction syndrome, swollen ankles appear, accompanied by chest tightness, breath-holding, and inability to lie down, when heart failure should be considered; 3. Liver diseases: liver diseases of various causes lead to cirrhosis, ascites, and swollen ankles; 4. Thyroid diseases: when hypothyroidism occurs, fatigue, weakness, and swelling of both lower limbs will appear; 5. Hypertension: patients taking calcium antagonists for a long time will have edema in the ankles; 6. Other diseases: such as severe malnutrition or Other diseases: such as severe malnutrition or moderate to severe anemia, also prone to ankle swelling or accompanied by facial edema.