Cryptococcus causes mainly central nervous system, pulmonary and cutaneous lesions, which can be life-threatening in severe cases. Disseminated lesions can also occur in the ends of long bones, joints, liver, spleen, kidneys, heart, testes, prostate, and other organs. Typically, affected tissues contain peptide-like yeast cysts, which are formed by the accumulation of polysaccharides in the cryptococcal cyst membrane, but have only mild or no acute inflammatory changes. In severe cases, sepsis may occur and spread to all organs of the body or even cause death. How is cryptococcal capsular polysaccharide accumulation diagnosed in terms of clinical manifestations? Let’s take a look below. Although cryptococcosis is a systemic infection, central nervous system infections are the most common. Although pulmonary infections are also common, they are often overlooked because the symptoms are not obvious, and damage to the skin, bones or other internal organs is less common. Central nervous system infections: Cryptococcal meningitis is the most common, usually with a slow onset, with no obvious symptoms at first, or as mild intermittent headache, which later becomes persistent and gradually worsens. 2.Pulmonary infection: primary pulmonary infections are generally less symptomatic, and most of those with lesions confined to the lungs are asymptomatic. The initial onset is often characterized by symptoms of upper sensation, followed by bronchitis or pneumonia, with low fever, cough, coughing up small amounts of mucous sputum, jelly-like sputum or blood sputum, chest tightness and weight loss; chest pain may be present when the pleura is invaded; signs are bronchitis or solid lung lesions, and chest films show that the lesions are mostly in the middle and lower fields of the lungs. 3, skin and mucous membrane cryptococcosis: rare, can be primary or secondary, the latter often coexist with meningeal and pulmonary lesions. About 10% to 15% of patients with systemic cryptococcosis have skin and mucosal damage, of which mucosal lesions are more common, often occurring in the nasal septum, gums, tongue, hard palate, soft palate, tonsils and pharynx. 4, bone and joint cryptococcosis: most of the systemic infection is part of the system, rarely occurs alone. The whole body bones can be involved, but the bony prominence, skull and spine are more. Joints are seldom involved, every secondary to adjacent skeletal lesions. 5, other: cryptococcosis of kidney, adrenal gland, liver, spleen, lymph nodes, muscle, pancreas, prostate, etc. is often part of systemic infection, are less common.