The four indicators of liver fibrosis mainly include laminin, type III procollagen, type IV collagen and hyaluronidase. 1. Laminin: Laminin is a unique structural protein in the basement membrane of the human body, which is directly proportional to the degree of hepatic fibrosis activity and the pressure of the portal vein. The index of laminin in normal human body is <130μg/ml. 2. Type III precollagen: This index is mainly used to reflect the synthesis of type III collagen in the liver, which is closely related to the degree of hepatic fibrosis. Normally, type III precollagen in normal human body is <120μg/ml. 3. Type IV collagen: Type IV collagen is an important part of the basement membrane, usually reflecting the renewal rate of basement membrane collagen in the body. When the content increases, it reflects the liver fibrosis process more sensitively. Normal type IV collagen value is <75μg/ml/L. 4. Hyaluronidase: Hyaluronidase is one of the components of matrix, synthesized by mesenchymal cells. It can clearly reflect the amount of fiber in the liver as well as the degree of liver damage, and the normal value is usually <110mg/L. For patients with poor liver function or patients suspected of having liver fibrosis, should follow the doctor’s instructions to check the four indicators of liver fibrosis, clear lesions and then timely treatment.