The content of antipyretic drugs and fever suppositories is the same and they are the same type of drugs, so it is not recommended to use antipyretic drugs and fever suppositories at the same time to avoid overdose and adverse consequences, but if the child’s persistent high fever is not relieved, the treatment can be applied in an overlapping way. While reducing the fever, it is important to improve the relevant tests to clarify which cause of the fever is caused, and according to the results of the symptomatic choice of antibiotics or antiviral, anti-flu drugs can be controlled. The fever-reducing drugs alone only play a role in reducing fever, but can not solve the underlying problem, in summary, fever-reducing drugs and fever suppositories should not be used together to avoid drug overdose reactions.