Since pancreatic cancer has no specific symptoms in the early stage, it is difficult to make a definite diagnosis in the early stage. Therefore, 85% of patients are diagnosed when the cancer has invaded the surrounding large blood vessels or organs and cannot be radically removed. Therefore, we should pay high attention to the high-risk group of pancreatic cancer. The Pancreatic Group of the Chinese Medical Association has formulated the concept of high-risk group of pancreatic cancer, as follows: 1. Those who are older than 40 years old, with no obvious cause of epigastric fullness and discomfort, abdominal pain, accompanied by weight loss. 2. Those who have a family history of pancreatic cancer. 3.Patients with sudden onset of diabetes mellitus, especially atypical diabetes mellitus, age over 60 years, lack of family history, no obesity, and soon become insulin resistant. 40% of pancreatic cancer patients have diabetes mellitus at the time of diagnosis. 4, Patients with chronic pancreatitis, chronic pancreatitis is an important precancerous lesion in a small percentage of patients, especially chronic familial pancreatitis and chronic calcific pancreatitis. 5, mucinous papillary tumors in the pancreatic ducts are also precancerous lesions. 6.Benign lesions with distal gastrectomy, especially those who are more than 20 years postoperative. 7. High risk factors for pancreatic cancer include smoking, heavy alcohol consumption, and long-term exposure to harmful chemicals. The above-mentioned conditions belong to the high risk group for pancreatic cancer and should be taken seriously. If necessary, abdominal ultrasound and CA199 test of peripheral blood should be performed. If abnormalities of the pancreas are found, further thin scan of the pancreas plus enhanced CT examination should be performed to clarify the diagnosis as early as possible and strive for surgical resection for the purpose of cure. In clinical practice, we often encounter many patients with epigastric fullness and discomfort and abdominal pain, who are misdiagnosed as chronic gastritis, given symptomatic treatment that is ineffective, and then undergo imaging examination when the symptoms are obviously aggravated and unbearable, and the cancer is already locally advanced and cannot be radically resected.