There is a possibility that tenosynovitis of the thumb may get better on its own without treatment, or if the condition is severe, medication, surgery, and general measures of conditioning are required. Thumb tenosynovitis is a self-limiting disease and may resolve on its own. If the condition is severe, it will not recover on its own and requires appropriate medication under the guidance of a doctor. In case of tuberculous tenosynovitis, anti-tuberculous drugs such as isoniazid and rifampicin are needed. If the patient develops acute plasma tenosynovitis, non-steroidal anti-inflammatory drugs, such as diclofenac sodium and indomethacin, as well as immunosuppressive drugs, such as methotrexate and azathioprine, are needed. If acute suppurative tenosynovitis is present, antibiotics such as cefixime and amoxicillin are required. For some cases of infectious tenosynovitis or acute plasma tenosynovitis, incision and drainage can be used to drain the pus out. In the case of stenosing tenosynovitis, tenotomy and decompression can be performed. The affected area can be massaged, rested, and immobilized in a plaster or splint if necessary. Thumb tenosynovitis may get better on its own. If the symptoms persist, the patient needs to consult a doctor and take appropriate measures as prescribed by the doctor.