Taking ibuprofen tablets for a headache can provide pain relief in most cases, however, the cause of the headache needs to be sought and targeted. Ibuprofen is a common clinical non-steroidal anti-inflammatory drug with antipyretic and analgesic effects. Ibuprofen antipyretic and analgesic effect, mainly after the drug is taken, through the inhibition of prostaglandin synthesis, can achieve the role of pain. Headache is a symptom that may be induced by poor sleep, mental factors, environmental factors, such as migraine, can be given ibuprofen tablets under the guidance of a doctor, which can effectively control the patient’s symptoms. A variety of diseases can cause headache, such as colds, hypertension, cervical spondylosis, cerebrovascular accidents and other diseases, can also cause headache. It is not recommended to directly take oral ibuprofen and other medications for pain relief, so as not to mask the condition. Instead, it is recommended to go to the hospital, combined with the doctor’s advice, for the primary disease treatment.