Case summary: Liang, an elderly man, is 76 years old. He is from Shijiazhuang, Hebei Province. He had a history of smoking for more than 50 years and had quit smoking for 8 years. He had a history of hypertension for 6-7 years, with a maximum blood pressure of 190/100 mmHg. No history of tuberculosis. He has been coughing and coughing white sputum intermittently for more than 10 years and has been taking oral medication on his own (details unknown). The old man insisted on annual physical examination and the chest X-ray was normal and no occupying lesions were found. In the past six months, Liang Cheng’s cough and white sputum worsened compared with the previous ones, and he took oral antibiotics on his own with poor effect. So Liang Cheng was hospitalized. After admission, further examination of the chest intensive CT suggested that the nodule foci in the posterior segment of the upper lobe of the left lung were about 2 cm in size, and the possibility of malignant nodules was considered. After consultation with Prof. Weijian Feng, the clinical consideration was that lung cancer was a high possibility and a puncture biopsy was recommended for pathology. However, Liang Cheng’s family refused the surgery and biopsy for pathology because of the patient’s advanced age. The family expressed that they only wanted to control the patient’s condition through painless treatment. Considering the patient’s condition and the family’s wishes, it was decided to perform CT-guided percutaneous tumor radiofrequency ablation treatment for the patient. During the treatment, the patient was positioned prone, the guide was positioned, the angle and depth of the puncture needle was measured (picture 1), CT showed the puncture needle pointing to the lesion (picture 2), hitting the proximal end of the tumor and treating it could quickly stop the bleeding to prevent implantation dissemination, the second target was the center of the tumor, opening the sub-electrode and covering the whole tumor (picture 3), two targets, the ablation boundary reached 5mm outside the tumor, 90℃, 20 minutes. The tumor was rapidly coagulated and necrotic. After the temperature of the target point was lowered from 90℃ to 40℃, the immune activating drug sapropterin 5KE was injected intra-tumorally. The whole treatment process was smooth and the patient had no special discomfort. Liang Cheng’s condition belongs to early stage, and surgery is currently the first choice for early lung cancer treatment, but clinics often encounter patients like Liang Cheng who refuse surgery. Radiofrequency ablation therapy has become the second best choice for patients with early stage lung cancer, which can achieve the same effect as surgical resection for tumors less than 5 cm in size. Elder Liang Cheng will have a review in 1 month and no further radiotherapy is needed due to the early stage of the tumor. Radiofrequency ablation has become a minimally invasive, convenient and effective treatment method for lung cancer patients.