The bleeding cannot be stopped commonly in the following diseases: i. Vascular rupture, which can be caused by trauma or re-bleeding from a ligated vessel after surgery, requires active rehydration, administration of hemostatic drugs, as well as surgical treatment as soon as possible, and blood transfusion to replenish blood volume if necessary. There are many causes of DIC, such as amniotic fluid embolism, massive bleeding, and severe infection, which require active treatment and have a high mortality rate. Third, the blood system diseases such as hemophilia, which is a genetic coagulation disorder, can not be cured, mainly to stop bleeding, blood replenishment and other treatment. If once the bleeding is more than one should promptly go to the hospital and actively treat to prevent life-threatening.