Parkinson’s disease and Parkinson’s syndrome, they are not a disease. The main differences are as follows: 1. The pathogenesis of Parkinson’s disease differs, after the unexplained degeneration and necrosis of nigrostriatal cells in the midbrain, the amount of dopamine synthesized and secreted by the residual nigrostriatal cells is significantly reduced. Dopamine is known to be a “pleasure” neurotransmitter that regulates human activity and mood, i.e., it assists the body in fine motor movements and puts the person in a state of excitement and pleasure. When its secretion is insufficient, the body will experience muscle stiffness, motor retardation, resting tremor, emotional anxiety, depression and so on. Parkinson’s syndrome, on the other hand, has a clear cause and is a group of diseases including secondary Parkinson’s syndrome, Parkinson’s superimposed syndrome and genetically degenerative Parkinson’s syndrome. They are related to genetics, cerebrovascular disease, traumatic brain injury, intracranial inflammation, brain tumors, brain damage caused by toxic substances or drugs, and the decrease in dopamine is secondary to brain disease. 2, the clinical manifestations are different. Patients with Parkinson’s disease have a later age of onset, while some Parkinson’s syndromes have a younger age of onset. The former usually has a unilateral onset, gradually involving the contralateral limb, mostly with resting tremor; the latter usually has a bilateral onset, with less tremor, usually with postural tremor and motor tremor. Parkinson’s syndrome may have balance disturbances, easy falling, and slurred spitting early on. Most brain MRI examinations in Parkinson’s disease patients are normal, while most MRI images in Parkinson’s syndrome patients are abnormal images. 3, treatment methods are diverse, the drug treatment of both diseases is supplemental dopamine, continuous dopamine therapy for Parkinson’s disease is more effective, and even have a “honeymoon” period of treatment; while dopamine therapy for Parkinson’s syndrome is generally effective, this type of syndrome requires “type-specific treatment This type of syndrome requires “type-specific” treatment. For example, secondary Parkinson’s syndrome requires treatment of the primary disease first; Parkinson’s superimposed syndrome requires concurrent treatment of dementia, postural hypotension, and urinary abnormalities. These diseases are usually treated at home with outpatient prescriptions and are less effective. It is now believed that patients with Parkinson’s disease and Parkinson’s syndrome should be regularly hospitalized for examination, treatment and rehabilitation, which is necessary to maintain long-term stable outcomes and will also reduce their anxiety and depression. 4, experts reminded that for the above two types of diseases, some serious patients can be treated with stereotactic surgery, such as the implementation of radiofrequency nucleus destruction surgery and deep brain electrical stimulation (DBS), after the operation of the patient’s clinical symptoms of stable improvement, helping them to restore their self-care ability and improve the quality of life.