Atrophic gastritis patients with symptoms can be treated according to the corresponding symptoms, such as the use of acid-suppressing drugs, drugs to protect the gastric mucosa, etc.; no symptoms suggest regular review of gastroscopy. 1. With clinical symptoms: (1) Acid-suppressing drugs: patients with chronic atrophic gastritis can be treated with drugs that inhibit the secretion of gastric acid, such as omeprazole, rabeprazole, etc., to alleviate patients’ discomfort. (2) Drugs to protect the gastric mucosa: patients can also use drugs to protect the gastric mucosa for treatment, such as magnesium aluminum carbonate, aluminum thiosulphate, bismuth pectin and other drugs, which can neutralize the gastric acid and form a protective layer on the surface of the gastric mucosa, which can play a very good protective effect on the gastric mucosa. (3) Drugs to eradicate Hp: Patients with chronic atrophic gastritis who have Hp infection can be treated with antimicrobial therapy using quadruple therapy, which includes a proton pump inhibitor, a bismuth agent, and two antibiotics, such as omeprazole, colloidal bismuth pectin, metronidazole, and amoxicillin. 2. No clinical symptoms: it is recommended to review gastroscopy regularly, mild to moderate atrophy with enterosis once every 3 years, and moderate to severe atrophy with enterosis once every 2 years; endoscopy and pathological examination are needed immediately when there is heterozygous hyperplasia, endoscopic follow-up after 3 months for mild heterozygous hyperplasia, and endoscopic treatment is needed for moderate to severe heterozygous hyperplasia. The above drugs should be used under the guidance of specialized physicians. Patients with chronic atrophic gastritis are advised to go to the hospital in time to avoid delays in treatment under the guidance of a doctor.