The biggest advancement in the field of liver disease in the last decade has to be the new hepatitis C drugs (DAA). The new hepatitis C drugs have many advantages over traditional interferon regimens: fewer side effects, all oral, significantly higher cure rates, and even close to 100% for some genotypes. And newer and better drugs are still being studied. The emergence of new hepatitis C drugs is a boon for all hepatitis C patients. Is the new drug so good that we can just take it? Of course not ！！！！！！ The choice of treatment plan, this must be consulted by a professional, up to date doctor!!! The application of new drugs also requires attention to drug interactions. Some drugs need to be avoided with new drugs. Some drugs need to be adjusted in dose with new drugs. There are also some drugs that need to be taken separately and at certain intervals when used together with new drugs. This article focuses on drug interactions, giving you a few examples, for example, the anti-arrhythmic drug amiodarone should not be combined with HARVONI (Jiji), sofosbuvir, daclastavir. Another example: some drugs may require dose adjustment when used in combination with newer drugs, but of course the specific problem is analyzed. For example, Jiji with commonly used proton pump inhibitors. We can see the chart below, yellow represents the possible need to adjust the dose. The dose may need to be adjusted for the combination of Ghidi with omeprazole, lansoprazole, esomeprazole, and pantoprazole. Of course the vast majority of drugs are safe to be used in combination with newer drugs. We also give an example. For example, it is safe to use Jiji in combination with alprazolam and lactulose. The following chart