Generally, after liver cancer reaches advanced stage, patients will suffer a lot physically, among which abdominal distension is one of the symptoms that often appear in the middle and advanced stages. Besides abdominal distension, what other symptoms are there in the middle and late stages of liver cancer? More than a few patients have pain in the liver area, which is equivalent to the location of the tumor and is mostly persistent distension or dull pain. Liver pain is caused by the rapid growth of tumor and the pulling of liver envelope. If the lesion invades the diaphragm, the pain may involve the right shoulder. When the cancer nodule ruptures, it may cause sudden and severe pain, and there are signs and symptoms of peritonitis. If the bleeding volume is large, it will cause syncope and shock. 2.hepatomegaly About 90% or more patients have enlarged liver with progressive enlargement, hard texture, uneven expression, nodules or giant lumps of different sizes, with blunt and uneven edges, and often with different degrees of pressure pain. When liver cancer protrudes under the right costal arch, or under the saber process, the epigastrium may show local elevation or fullness. If the cancer is located on the diaphragmatic surface, the main manifestation is the elevation of the diaphragm without enlargement of the lower edge of the liver. As the arterial vessels of hepatocellular carcinoma are rich and twisted, or the inner diameter of artery suddenly narrows due to the compression of hepatic artery or abdominal aorta by huge carcinoma, blowing wind-like vascular murmur can sometimes be heard on the abdominal wall close to the tumor. 3.Jaundice usually appears in late stage, which can be caused by hepatocellular damage, or due to compression of cancer mass, or invasion of bile duct near hepatoportal, or detachment of cancer tissue and blood clot, causing biliary obstruction. 4.Signs of cirrhosis Patients with cirrhotic portal hypertension may have splenomegaly, ascites, formation of venous collateral circulation and other manifestations. The ascites increases quickly and is usually leaking fluid. Hemorrhagic ascites is mostly caused by cancer invading the peritoneum or breaking into the abdominal cavity, and occasionally caused by peritoneal metastasis. 5.Systemic manifestations of malignant tumor include progressive wasting, fever, loss of appetite, weakness, malnutrition and cachexia, etc. A few patients with liver disease may have special systemic manifestations, which are called concomitant cancer syndrome. 6.Metastasis symptoms If metastasis occurs in lung, bone, chest, etc., corresponding symptoms can be produced. Thoracic metastasis is more common on the right side, and there may be pleural effusion sign. Bone or spine metastasis may have local pressure pain or nerve compression symptoms, and intracranial metastasis cancer may have nerve localization signs.