The treatment of liver cancer is valuable to early detection, early diagnosis and early treatment in order to improve the cure rate. However, treating patients with middle and late stage liver cancer, going for radical cure is not only difficult for the patients themselves to bear the trauma of surgery and toxic side effects brought by chemotherapy or radiotherapy, but also makes the quality of life decrease and shorten the life span. In the face of a large number of patients with mid- to late-stage liver cancer, the treatment concept of liver cancer should be updated, and the method of strengthening the spleen and supporting the righteousness can control the disease and allow patients to “live with tumor” and prolong their lives. A group of experts from the Chinese Academy of Traditional Chinese Medicine has applied Chinese medicine to treat patients with advanced liver cancer who have spleen deficiency and found that it can better control cancer pain, improve appetite, enhance physical strength, invigorate spirit, improve sleep, effectively eliminate or reduce patients’ symptoms, and improve cellular and humoral immunity to varying degrees. Clinical practice proves that, for patients with mid- to late-stage cancer, Chinese medicine treatment given according to specific conditions can comprehensively regulate the internal environment of the body, bring the imbalanced yin and yang into balance and harmony, and enhance the body’s ability to fight cancer. The U.S. Food and Drug Administration has included the improvement of tumor patients’ survival quality and prolongation of survival time as an important indicator in the evaluation standard of tumor efficacy. This new concept of tumor treatment has been accepted by more and more clinicians and patients as an important indicator of liver cancer treatment efficacy examination. For advanced liver cancer that has lost the opportunity of surgery and interventional treatment, the focus of TCM treatment is not on the tumor, but on the improvement of symptoms. The TCM treatment plan at this time can be illustrated by this prescription: anti-cancer prescription = symptomatic medication to improve symptoms (60%) + anti-cancer medication (40%). In other words, if there are ten herbs in a prescription, at least six of them are used to improve the patient’s symptoms. If the patient has poor liver function with ascites, add Che Qian Cao, Abdominal Water Cao, River White Cao, etc. to diuretic; if the patient has nausea and vomiting, add Su Stem, Fuxia, etc. to harmonize the stomach and stop vomiting; if the patient has abdominal distension, add Dagong Pi, Mu Xiang, Hou Pu, Betel Nut, etc. to move Qi and eliminate distension; if the patient has jaundice, often add Mian Yin Chen, Tian Ji Huang, etc. to promote dampness and reduce yellow; if the patient has pain, add Yu Jin, Yan Hu Suo, etc. to activate blood and relieve pain. In conclusion, through the evidence-based treatment of Chinese medicine, it has been widely accepted for patients with middle and late stage liver cancer to “survive with tumor” and improve their quality of life.