Liver cancer is the result of many factors, and genetic factors are also one of them, but it cannot be said that liver cancer is hereditary. The occurrence of liver cancer is related to the activation of oncogenes and inactivation of oncogenes, but it is mainly the result of gradual accumulation of various mutations. There is no exact oncogene, so people with family history have certain susceptibility to liver cancer, but it cannot be said that liver cancer is necessarily hereditary. Although there is no definite liver cancer gene that can be inherited, the development of liver cancer does have some family aggregation, which may be related to other factors other than genetics. For example, hepatitis B is one of the important factors leading to liver cancer, but hepatitis B is contagious and family members who live together for a long time are often the most likely to be infected, which leads to family aggregation of liver cancer, but this is not caused by the genetic inheritance of liver cancer. Other common causative factors of liver cancer, such as alcoholic lifestyle, aflatoxin contamination, schistosomiasis infection, etc., also have the phenomenon of family aggregation, which also lead to family aggregation of liver cancer, but these factors have preventive means. Therefore, people with family history have certain susceptibility to liver cancer, but it does not mean that liver cancer is necessarily hereditary. Some causative factors of liver cancer may appear familial, but basically, there are preventive measures, so there is no need to have psychological burden.