Bubbles in the lungs are clinically considered as pulmonary blisters, which are formed by the fusion of several alveoli. Small pulmonary blisters are clinically asymptomatic and do not require special treatment. The main risk of pulmonary bullae is pneumothorax. If the pulmonary bullae are large and affect lung function or if the pulmonary bullae are repeatedly pneumothoraxed and are relatively limited, they can be surgically removed. If there are more pulmonary blisters and they are scattered in two lung subdivisions, there is no clinical indication for surgery and there is a significant decrease in lung function, glucocorticoids or bronchodilators can be inhaled to relieve the symptoms of pneumothorax, and the commonly used drugs in clinical practice include salbutamol, ipratropium bromide, tiotropium bromide, etc. Pulmonary maculopathy, if combined with bacterial infection, requires aggressive antibiotic treatment to avoid life-threatening complications.