The liver is in a state of detoxification 24 hours a day, but the best time to detoxify is between 11pm and 2am. There is no exact time for liver detoxification, but it is usually a continuous process of breaking down and combining the toxins produced by metabolism in the body as well as the toxins invading into the body from outside, and then eliminating them from the body. At night when the body goes to sleep, the blood supply to the body parts decreases and the blood supply to the liver parts increases, so the effect of detoxification will also increase. In our daily life, we should develop good sleeping habits, go to bed early and get up early to avoid prolonged late-night sleep irregularities, to prevent affecting the normal functioning of the liver, and should also ensure that the diet is light and easy to digest, and appropriate exercise, to improve the immune ability of the body to promote liver detoxification has a more positive significance.