Big toe gout can be relieved by oral medication, such as colchicine, diclofenac sodium and other pain relievers, and short-term use of hormone therapy, such as prednisone, dexamethasone and so on, if necessary. Colchicine is the drug of choice for gouty attacks, used to treat acute attacks of gouty arthritis, can inhibit local cell production of interleukin-6 and other inflammatory mediators, to achieve the effect of relieving joint pain, usually 24 to 48 hours after taking the drug pain can disappear. The main adverse reactions are diarrhea, occasionally leukopenia, contraindicated for those who are allergic to it. Diclofenac sodium is an antipyretic and analgesic drug, which has a certain relief effect on the attack of gouty arthritis, and is mainly used for the treatment of inflammatory pain caused by various reasons. It is contraindicated for those with peptic ulcers and bleeding, those who are allergic to NSAIDs, and the main adverse reactions are abdominal pain, nausea, and peptic ulcers. Hormones are mainly applied to patients with obvious pain and poor results after the use of the above drugs, glucocorticoids such as prednisone and dexamethasone can be used for a short period of time. Note that uric acid-lowering therapy is not recommended during gout attacks. Big toe gout attack, it is recommended to go to the hospital for treatment, under the guidance of the physician medication treatment, do not self-medication.