Lymph node aspiration biopsy is performed with mild pain throughout the procedure and is usually performed under local anesthesia. Care should be taken to avoid injury to adjacent tissues, mainly superficial lymph nodes, nerves or blood vessels, and preferably under ultrasound guidance. If the patient is in significant pain, regional or local block anesthesia can be reapplied, and in patients with suspected malignant lymph node metastases, repeated punctures or twists should be avoided, leading to the possibility of lymph node implantation or metastasis. After surgery, local pressure bandages should be applied, and if pain is obvious, oral pain medication, such as aminoglutethimide tablets or oral nimesulide capsules, can be used to reduce discomfort.