Whether lymph node puncture leads to localized lesions is generally analyzed objectively depending on the specific nature of the lesion at the puncture site. First, if the lesion at the puncture site is benign, such as an inflammatory lesion in the neck leading to lymph node enlargement. There are no malignant tumor cells in the patient’s body, and fine needle aspiration biopsy of lymph nodes will not cause cancerous changes in the body tissue. If the lymph nodes of patients are caused by malignant tumor cells metastasis, the fine needle aspiration at this time may prompt the tumor cells to metastasize with the needle pathway. This may cause the systemic spread of malignant tumor, which is one of the common complications of puncture operation. For lesions with a higher possibility of malignancy, complete surgical excision is recommended, and puncture is not recommended to avoid cancer metastasis.