Rheumatic diseases are a group of diseases that mainly affect joints, bones, muscles, blood vessels and related soft or connective tissues, most of which are autoimmune diseases. Most of them are autoimmune diseases. The onset of disease is insidious and slow, with a long course, and most of them have a genetic predisposition. Diagnosis and treatment are difficult; different autoantibodies can be detected in the blood, which may be related to different HLA subtypes; good short-term or long-term remission response to non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and immunosuppressive drugs. Because rheumatism is a collective term for more than 100 diseases, not a single disease, it is incorrect to affirm in general that rheumatism is caused by “rheumatism” or to deny in general that rheumatism is not caused by “rheumatism”. In rheumatism, only part of the disease onset and the ancestral medicine so-called “rheumatism” and other environmental pathogenic factors, while others are caused by trauma, strain, degeneration, genetics, immune disorders, metabolic abnormalities and other factors. Some common factors related to the development of rheumatism are briefly described as follows: 1, immune disorders Immune function is a special defense function of higher animals, including people. It is because of the existence of immune function that the human body can mobilize the group’s defense force to eliminate pathogenic microorganisms such as bacteria when they invade; it is because of the existence of immune function that individual cells of the body can be removed in time when mutations occur to prevent the occurrence of tumors. Any cause of immune dysfunction, whether congenital or acquired; any form of abnormal immune function, whether hypo- or hyper-immune, will cause the body to develop diseases. In recent years, it has been found that under certain special circumstances, such as the body’s immune system malfunctioning and unable to accurately identify its own tissues or the antigenicity of certain tissues of the body changing, the body will also have an immune response to its own tissues, causing tissue damage and resulting in disease, called autoimmune diseases. In rheumatic diseases, many diseases such as rheumatoid arthritis, rheumatoid arthritis, systemic lupus erythematosus and tumors, the onset of which are related to immune dysfunction. 2, environmental factors A department of rheumatism, such as rheumatic cold arthritis, the onset of cold, dark, humid, sweat when the wind and other environmental factors are closely related. Wang Zhaoming, a researcher at the Tianjin Institute of Traditional Chinese Medicine, had a census of 1,000 workers in the alpine region of the Daxinganling Forest, the incidence of rheumatic arthralgia was as high as 77.9%. Some other rheumatic diseases, such as rheumatoid arthritis, ankylosing spondylitis, etc., its onset although not mainly because of environmental factors, but many patients have a history of living or working in cold, dark and humid environments, suggesting that environmental factors are likely to be the triggering factors for the onset of these patients. 3, infection Bacteria, viruses and other pathogenic microorganisms infect the human body, can enter the joint tissue with the blood circulation, at this time, if the body’s resistance is low, the pathogenic microorganisms can reproduce in the joint, damage the joint tissue, resulting in the occurrence of disease. For example, if Mycobacterium tuberculosis invades a joint, it can cause tuberculous arthritis; if Staphylococcus aureus and other septic bacteria invade a joint, it can cause septic arthritis. There are also arthritis that are not caused by the direct invasion of pathogenic microorganisms into the joints because the corresponding pathogenic bacteria cannot be found in the affected joints, but there are many indications that the infection is still associated with certain pathogenic microorganisms. For example, in patients with rheumatoid arthritis, no germs are found in the joints, but the onset and recurrence of the disease is clearly associated with Streptococcus haemolyticus infection. Some patients with tuberculosis often present with multiple joint swelling and pain, and sometimes erythema similar to rheumatoid arthritis, but anti-rheumatic treatment is ineffective, and joint symptoms snow sue improve or disappear after anti-tuberculosis treatment, which some people call tuberculous rheumatism. The disease is supported by history to treatment related to tuberculosis bacillus infection, but even when the joint swelling and pain, the joint tissue and joint cavity failed to find tuberculosis bacillus. 4. Trauma and strain Acute injury to the joints can cause traumatic arthritis in the affected joints. Acute sprains of the lower back can cause lumbar disc herniation. Some other diseases, such as the fairly common chronic lower back strain, tenosynovitis, etc., the affected part often has a history of long-term overwork, this chronic accumulative injury can also cause congestion, edema, adhesions of the affected tissue and lead to the development of disease. 5, degeneration that is degenerative changes, also known as “aging”. As with youth, middle age and old age, the tissues and organs of the human body also gradually age with age. The nature, form and function of degenerated tissues and organs will change. If you recognize this law and pay attention to protect them, the degeneration process can be delayed as much as possible. If you violate this law and force the degenerated tissues and organs to do the work they cannot do, it will not only accelerate the progress of degeneration, but also may cause damage to the tissues and organs and lead to disease. In rheumatic diseases, proliferative arthritis, proliferative spondylitis and many other diseases are related to degeneration. It should be noted that the degeneration of cartilage tissue is the most prominent among rheumatic diseases, and both of the above-mentioned diseases are caused by the degeneration of cartilage. This is because cartilage is not only burdened with a large workload, but also cartilage itself has almost no ability to repair and regenerate. Therefore, compared with other tissues and organs of the body, the appearance of cartilage degeneration is quite early, for example, intervertebral disc degeneration can occur after the age of 20. Therefore, the protection of cartilage tissue is very necessary. 6, genetic factors in rheumatic diseases in some diseases have a clear tendency of family inheritance. Rheumatoid arthritis and ankylosing spondylitis, for example, are often found in the clinical work of patients with similar diseases in the families of the two diseases. According to domestic and international reports, the prevalence of rheumatoid arthritis patients’ families is 2-10 times higher than that of the control group; while the prevalence of ankylosing spondylitis patients’ families differs by as much as 40 times compared to the control group. 7, metabolic disorders With the gradual study of rheumatic diseases, people found that the onset of some rheumatic diseases may be caused by the body’s metabolic disorders of certain types of substances. Typical examples are gout and pseudogout, the former for purine metabolism disorders, the latter may be related to inorganic pyrophosphate metabolism disorders. The above lists some common factors related to the development of rheumatism, it should be noted that: ① the list here is only some common causes, and is not comprehensive. ②There are still a considerable number of rheumatic diseases whose causes are still unknown. (3) the onset of many rheumatic diseases is the result of a combination of the above factors.