Emphysema is a pathological change that cannot be reversed by itself. Whether a patient is able to run depends on the patient’s lung function and underlying disease. 1. Lung function: Patients with emphysema tend to develop obstructive ventilatory dysfunction, which gradually develops into chronic obstructive pulmonary disease (COPD) or is combined with huge pulmonary blisters. When combined with moderate-to-severe ventilation dysfunction or huge pulmonary blisters, the patient’s activity endurance is significantly reduced, and only able to complete daily life. Running is not recommended if the patient is unable to tolerate high-intensity exercise such as running. 2. Underlying diseases: If emphysema patients are combined with chronic cardiac insufficiency, unstable angina pectoris, acute cerebrovascular disease, etc., it is not recommended to run strenuously, which may lead to hypoxia and aggravate the burden on the cardio-cerebral system. In conclusion, for people with emphysema, it is recommended to choose the appropriate intensity of activity in daily life according to personal conditions and under the advice of doctors.