Knee pain after walking too much can be relieved through rest, physical therapy, medication and other methods. 1. Rest: knee pain after walking too much can usually be effectively relieved by rest. 2. Physical therapy: you can also choose hot compresses, massage and other physical therapy to relieve pain, hot compresses should pay attention to the temperature is not too high, to avoid burns. 3. Medication: If the pain is severe, you can take non-steroidal anti-inflammatory analgesic drugs, such as Celecoxib, Erythroxib, ibuprofen and so on to relieve the pain, and you can also use topical diclofenac diethylamide emulsion and other drugs. Both massage and medication should be administered under medical supervision. If the knee pain is severe or cannot be relieved, you should go to the hospital in time for treatment under the guidance of your doctor.