Nausea and vomiting in patients with insomnia are associated with plant nerve dysfunction. All digestive tracts, as well as digestive organs, are subject to dual innervation by sympathetic and parasympathetic nerves, which act together to regulate the movement of the smooth muscles of the digestive tract, glandular secretion, and vascular activity. When autonomic dysfunction occurs, patients often have sympathetic hyperactivity, which causes contraction of the smooth muscles and sphincters of the GI tract. Patients experience gastrointestinal spasms, with nausea, regurgitation and, in severe cases, vomiting. First of all, the patient should improve sleep and can take oral sleep-promoting drugs, commonly used are alprazolam, clonidine, zolpidem, dexrazoxane, etc. If nausea still exists after sleep improvement, oral Mosapride can be taken to regulate the gastrointestinal function.