Most people have no obvious reaction after receiving the 13-valent pneumonia vaccine. A few people may have fever, skin symptoms and digestive abnormalities after receiving the vaccine. 1. Fever: After receiving 13-valent pneumonia vaccine, there may be different degrees of fever, most of which are low or moderate, with body temperature not exceeding 38 degrees, and usually return to normal 48 hours after vaccination. 2. Skin symptoms: after vaccination, some people may have adverse symptoms such as swelling, tenderness and hardness at the injection site, which usually subside naturally 48 hours after vaccination. 3. Digestive system abnormalities: nausea, diarrhea and other symptoms after vaccination. After vaccination with 13-valent pneumonia vaccine, the above reactions are normal side effects, as long as the situation is not serious, you can first focus on observation. However, if serious symptoms such as angioneurotic edema and dyspnea occur after vaccination, you need to go to the hospital at the first time for medical examination and treatment under the guidance of a professional doctor to avoid delaying your condition.